Dual Key‐Activated Nir‐I/II Fluorescence Probe for Monitoring Photodynamic and Photothermal Synergistic Therapy Efficacy

Abstract

AbstractAs cancer markers, hydrogen peroxide (H2O2) and viscosity play an essential role in the development of tumors. Meanwhile, based on the performance of near‐infrared (NIR) fluorescence imaging and the high efficiency of photodynamic therapy (PDT) and photothermal therapy (PTT) synergistic therapy, it is urgent to develop a dual‐key (H2O2 and viscosity) activated fluorescence probe for cancer phototherapy. Herein, a NIR‐I/II fluorescence probe named BX‐B is reported. In the presence of both H2O2 and viscosity, the fluorescence signal of NIR‐I (810 nm) and NIR‐II (945 nm) can be released. In the presence of H2O2, the PDT and PTT effects are observed. BX‐B is used to monitor its therapeutic effects in cancer cells and tumor‐bearing mice due to the increased viscosity caused by PDT and PTT. In addition, the tumors of mice treated with BX‐B are almost completely ablated after the laser irradiation based on its PDT and PTT synergistic therapy. This work provides a reliable platform for effective cancer treatment and immediate evaluation of therapeutic effects.