Affiliation:
1. School of Pharmacy and Food Engineering Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine Wuyi University Jiangmen 529020 P. R. China
2. International Healthcare Innovation Institute (Jiangmen) Jiangmen 529040 P. R. China
3. Instrumental Analysis and Research Center South China Agricultural University Guangzhou 510642 China
4. School of Biomedical Engineering Guangzhou Medical University Guangzhou 511495 P. R. China
Abstract
AbstractThe complex preparation, weak wet tissue adhesion, and limited biological activity of traditional oral wound dressings usually impede their efficient treatment and healing for diabetic oral mucosal defects. To overcome these problems, a novel hydrogel adhesive (named CFT hydrogel) is rapidly constructed using a one‐step method based on dual‐dynamic covalent cross‐linking. Compared with the commercial oral patches, the CFT hydrogel shows superior in vivo (rat tongue) wet tissue adhesion performance. Additionally, the CFT hydrogel exhibits unique acid‐responsive properties, thereby facilitating the release of bioactive molecule tannic acid in the acidic diabetic wound microenvironment. And a series of in vitro experiments substantiate the favorable biocompatibility and bioactivity properties (including antibacterial, antioxidative, anti‐inflammatory, and angiogenetic effects) exhibited by CFT hydrogel. Moreover, in vivo experiments conducted on a diabetic rat model with oral mucosal defects demonstrate that the CFT hydrogel exhibits significant efficacy in protecting against mucosal wounds, alleviating inflammatory reactions, thereby facilitating the wound‐healing process. Taken together, this study provides a promising and comprehensive therapeutic option with great potential for the clinical management of oral mucosa defects in diabetic patients.
Funder
National Natural Science Foundation of China
Department of Education of Guangdong Province
Science and Technology Planning Project of Guangdong Province
Cited by
4 articles.
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