Affiliation:
1. Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing School of Stomatology Lanzhou University Gansu Province Lanzhou 730000 P. R. China
Abstract
AbstractPeripheral nerve defects, particularly those of a larger size, pose a significant challenge in clinical practice due to their limited regenerative capacity. To tackle this challenge, an advanced self‐powered enzyme‐linked microneedle (MN) nerve conduit is designed and fabricated. This innovative conduit is composed of anodic and cathodic MN arrays, which contain glucose oxidase (GOx) and horseradish peroxidase (HRP) encapsulated in ZIF‐8 nanoparticles, respectively. Through an enzymatic cascade reaction, this MN nerve conduit generates microcurrents that stimulate the regeneration of muscles, blood vessels, and nerve fibers innervated by the sciatic nerve, eventually accelerating the repair of sciatic nerve injury. It is clear that this self‐powered MN nerve conduit will revolutionize traditional treatment methods for sciatic nerve injury and find widespread application in the field of nerve tissue repair.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Gansu Province
Fundamental Research Funds for the Central Universities
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
6 articles.
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