Affiliation:
1. Institute of Biological Information Processing – Bioelectronics IBI‐3 Forschungszentrum Jülich 52428 Jülich Germany
2. Neuroelectronic Interfaces RWTH Aachen 52074 Aachen Germany
3. Faculty of Engineering and Natural Sciences Tampere University Tampere FI‐33720 Finland
4. Interdisciplinary Nanoscience Center – INANO‐Fysik Aarhus University Aarhus 8000 Denmark
5. Center for Advanced Biomaterials for Healthcare Italian Institute of Technology Naples 80125 Italy
6. Dipartimento di Chimica, Materiali e Produzione Industriale University Federico II of Naples Naples 80125 Italy
Abstract
AbstractSignificant challenges have emerged in the development of biomimetic electronic interfaces capable of dynamic interaction with living organisms and biological systems, including neurons, muscles, and sensory organs. Yet, there remains a need for interfaces that can function on demand, facilitating communication and biorecognition with living cells in bioelectronic systems. In this study, the design and engineering of a responsive and conductive material with cell‐instructive properties, allowing for the modification of its topography through light irradiation, resulting in the formation of “pop‐up structures”, is presented. A deformable substrate, composed of a bilayer comprising a light‐responsive, azobenzene‐containing polymer, pDR1m, and a conductive polymer, PEDOT:PSS, is fabricated and characterized. Moreover, the successful formation of supported lipid bilayers (SLBs) and the maintenance of integrity while deforming the pDR1m/PEDOT:PSS films represent promising advancements for future applications in responsive bioelectronics and neuroelectronic interfaces.
Funder
Carlsbergfondet
Emil Aaltosen Säätiö
H2020 European Research Council