Harnessing Human Placental Membrane‐Derived Bioinks: Characterization and Applications in Bioprinting and Vasculogenesis

Author:

Comperat Léo123,Chagot Lise123,Massot Sarah123,Stachowicz Marie‐Laure123,Dusserre Nathalie123ORCID,Médina Chantal123,Desigaux Théo123,Dupuy Jean‐William14,Fricain Jean‐Christophe124,Oliveira Hugo123

Affiliation:

1. University of Bordeaux Tissue Bioengineering U1026 Bordeaux F‐33076 France

2. Inserm U1026 Tissue Bioengineering ART BioPrint Bordeaux F‐33076 France

3. CHU Bordeaux Services d'Odontologie et de Santé Buccale Bordeaux F‐33076 France

4. University of Bordeaux Plateforme Protéome Bordeaux 33000 France

Abstract

AbstractBioprinting applications in the clinical field generate great interest, but developing suitable biomaterial inks for medical settings is a challenge. Placental tissues offer a promising solution due to their abundance, stability, and status as medical waste. They contain basement membrane components, have a clinical history, and support angiogenesis. This study formulates bioinks from two placental tissues, amnion (AM) and chorion (CHO), and compares their unique extracellular matrix (ECM) and growth factor compositions. Rheological properties of the bioinks are evaluated for bioprinting and maturation of human endothelial cells. Both AM and Cho‐derived bioinks sustained human endothelial cell viability, proliferation, and maturation, promoting optimal vasculogenesis. These bioinks derived from human sources have significant potential for tissue engineering applications, particularly in supporting vasculogenesis. This research contributes to the advancement of tissue engineering and regenerative medicine, bringing everyone closer to clinically viable bioprinting solutions using placental tissues as valuable biomaterials.

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biomaterials

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3