Combining Chitosan, Stearic Acid, and (Cu‐, Zn‐) MOFs to Prepare Robust Superhydrophobic Coatings with Biomedical Multifunctionalities

Author:

Zhang Jianwen1ORCID,Pei Xinyu1,Liu Yihan1,Ke Xianlan1,Peng Ya2,Weng Yajun3,Zhang Qinyong2,Chen Junying1

Affiliation:

1. Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Chengdu 610031 P. R. China

2. School of Materials Science and Engineering Xihua University Chengdu Sichuan 610039 China

3. Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu Sichuan 610031 China

Abstract

AbstractThere is an urgent need to develop a series of multifunctional materials with good biocompatibility, high mechanical strength, hemostatic properties, antiadhesion, and anti‐infection for applications in wound care. However, successfully developing multifunctional materials is challenging. In this study, two superhydrophobic composite coatings with good biocompatibility, high mechanical strength, strong antifouling and blood repellency, fast hemostasis, and good antibacterial activity are prepared on cotton fabric surface by simple, green, and low‐cost one‐step dip‐coating technology. The results discussed in the manuscript reveals that the two superhydrophobic composite coatings can maintain good mechanical stability, strong water repellency, and durability under various types of mechanical damage, high‐temperature treatment, and long‐term strong light irradiation. The coatings also exhibit good repellency to various solid pollutants, highly viscous liquid pollutants, and blood. In vitro and in vivo hemostatic experiments show that both composite coatings have good hemostatic and anticlot adhesion properties. More importantly, this superhydrophobic coating prevents bacterial adhesion and growth and released Cu2+ and Zn2+ ions and chitosan to achieve bactericidal properties, thereby protecting injured skin from bacterial infection. The two superhydrophobic coatings enhance the antifouling, antiadhesion, hemostatic, and antibacterial functions of blood‐repellent dressings and therefore have broad application prospects in medical and textile fields.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Natural Science Foundation of Sichuan Province

Fundamental Research Funds for the Central Universities

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biomaterials

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