Affiliation:
1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry and Chemical Engineering Donghua University Shanghai 201620 China
2. Shanghai Engineering Research Center of Nano‐Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University Shanghai 201620 China
Abstract
AbstractTherapies for wound infections require medications with antibacterial and wound‐healing functions. However, it remains a challenge to produce a single drug that can perform dual functions. Nitric oxide (NO), with its antibacterial and wound‐healing activities, is an ideal solution to address this challenge. However, many controlled‐release strategies for NO rely on external probes for tracing the release in situ, making it difficult to precisely assess the location and magnitude. To address this issue, this study describes a novel NO donor, DHU‐NO1, capable of efficiently releasing NO under mild conditions (450 nm illumination). Simultaneously, DHU‐NO1 generates the fluorophore Azure B (AZB), which enables direct, non‐consumptive tracing of the NO release by monitoring the fluorescence and absorption changes in AZB. Given that NO can be conveniently traced, the amount of released NO can be controlled during biological applications, thereby allowing both functions of NO to be performed. When applied to the affected area, DHU‐NO1, illuminated by both a simple light‐emitting diode (LED) light source and natural light, achieves significant antibacterial effects against wound infections and promotes wound healing in mice. This study offers a novel and effective approach for treating wound infections.
Funder
National Natural Science Foundation of China