Toxicology-based cancer causation analysis of CoCr-containing hip implants: a quantitative assessment of genotoxicity and tumorigenicity studies

Author:

Christian Whitney V.1,Oliver Lindsay D.2,Paustenbach Dennis J.3,Kreider Marisa L.1,Finley Brent L.4

Affiliation:

1. Cardno ChemRisk, LLC; 20 Stanwix St., Suite 505 Pittsburgh PA 15222 USA

2. Cardno ChemRisk; LLC, 4840 Pearl East Circle, Suite 300 West Boulder CO 80301 USA

3. Cardno ChemRisk; LLC, 970 W. Broadway, Suite E Jackson WY 83002 USA

4. Cardno ChemRisk; LLC, 231 Front St., Suite 201 Brooklyn NY 11201 USA

Funder

DePuy Orthopaedics, Inc.

Publisher

Wiley

Subject

Toxicology

Reference193 articles.

1. Distribution of metal released from cobalt-chromium alloy orthopaedic wear particles implanted into air pouches in mice;Afolaranmi;J. Biomed. Mater. Res. A,2012

2. Oxidative stress contributes to cobalt oxide nanoparticles-induced cytotoxicity and DNA damage in human hepatocarcinoma cells;Alarifi;Int. J. Nanomedicine,2013

3. Assessment of reference values for selected elements in a healthy urban population;Alimonti;Ann. Ist. Super. Sanita,2005

4. Metal on metal total hip replacement workshop consensus document;Amstutz;Clin. Orthop.,1996

5. In vitro genotoxic effects of hard metal particles assessed by alkaline single cell gel and elution assays;Anard;Carcinogenesis,1997

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