Superfluous glutamine synthetase activity in Chinese Hamster Ovary cells selected under glutamine limitation is growth limiting in glutamine‐replete conditions and can be inhibited by serine-Reference-Cited by-同舟云学术

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Superfluous glutamine synthetase activity in Chinese Hamster Ovary cells selected under glutamine limitation is growth limiting in glutamine‐replete conditions and can be inhibited by serine

Published:2019-06-12 Issue:5 Volume:35 Page:
ISSN:8756-7938
Container-title:Biotechnology Progress
language:en
Short-container-title:Biotechnol. Prog.

Author:

Maralingannavar Vishwanathgouda¹²,Parmar Dharmeshkumar¹²,Panchagnula Venkateswarlu¹²,Gadgil Mugdha¹²^ORCID

Affiliation:

1. Chemical Engineering and Process Development DivisionCSIR‐National Chemical Laboratory Pune Maharashtra India

2. Academy of Scientific and Innovative Research (AcSIR)CSIR‐National Chemical Laboratory Campus Ghaziabad Uttar Pradesh India

Funder

Department of Biotechnology , Ministry of Science and Technology

Department of Science and Technology, Ministry of Science and Technology

Publisher

Wiley

Subject

Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/btpr.2856

Reference50 articles.

1. The importance of ammonia in mammalian cell culture

2. Substitution of Glutamine by Pyruvate To Reduce Ammonia Formation and Growth Inhibition of Mammalian Cells

3. Improvement of CHO Cell Culture Medium Formulation: Simultaneous Substitution of Glucose and Glutamine

4. Substitution of glutamine by glutamate enhances production and galactosylation of recombinant IgG in Chinese hamster ovary cells

5. CHO-K1 host cells adapted to growth in glutamine-free medium by FACS-assisted evolution

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