Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer

Author:

Kho Pik‐Fang12,Amant Frederic3,Annibali Daniela3,Ashton Katie456,Attia John47,Auer Paul L.89,Beckmann Matthias W.10,Black Amanda11,Brinton Louise11,Buchanan Daniel D.12131415ORCID,Chanock Stephen J.16,Chen Chu17ORCID,Chen Maxine M.18,Cheng Timothy H. T.19,Cook Linda S.2021,Crous‐Bous Marta1822,Czene Kamila23,De Vivo Immaculata1822ORCID,Dennis Joe24,Dörk Thilo25ORCID,Dowdy Sean C.26,Dunning Alison M.27,Dürst Matthias28,Easton Douglas F.2427,Ekici Arif B.29,Fasching Peter A.1030ORCID,Fridley Brooke L.31,Friedenreich Christine M.21ORCID,García‐Closas Montserrat16,Gaudet Mia M.32ORCID,Giles Graham G.133334,Goode Ellen L.35ORCID,Gorman Maggie19,Haiman Christopher A.36,Hall Per2337,Hankinson Susan E.2238,Hein Alexander10,Hillemanns Peter25,Hodgson Shirley39,Hoivik Erling A.4041,Holliday Elizabeth G.47,Hunter David J.184243,Jones Angela19,Kraft Peter1842,Krakstad Camilla4041,Lambrechts Diether4445,Le Marchand Loic46,Liang Xiaolin47,Lindblom Annika4849,Lissowska Jolanta50,Long Jirong51,Lu Lingeng52ORCID,Magliocco Anthony M.53,Martin Lynn54,McEvoy Mark7,Milne Roger L.133334,Mints Miriam55,Nassir Rami56,Otton Geoffrey57,Palles Claire19,Pooler Loreall36,Proietto Tony57,Rebbeck Timothy R.5859,Renner Stefan P.60,Risch Harvey A.52,Rübner Matthias60,Runnebaum Ingo28,Sacerdote Carlotta6162ORCID,Sarto Gloria E.63,Schumacher Fredrick64,Scott Rodney J.4665,Setiawan V. Wendy36,Shah Mitul27,Sheng Xin36,Shu Xiao‐Ou51ORCID,Southey Melissa C.123334,Tham Emma4866,Tomlinson Ian1954,Trovik Jone4041,Turman Constance18,Tyrer Jonathan P.27,Van Den Berg David36,Wang Zhaoming11ORCID,Wentzensen Nicolas11ORCID,Xia Lucy36,Xiang Yong‐Bing67ORCID,Yang Hannah P.11,Yu Herbert46ORCID,Zheng Wei51,Webb Penelope M.68,Thompson Deborah J.24,Spurdle Amanda B.1ORCID,Glubb Dylan M.1,O'Mara Tracy A.1ORCID

Affiliation:

1. Department of Genetics and Computational Biology QIMR Berghofer Medical Research Institute Brisbane Queensland Australia

2. School of Biomedical Science Queensland University of Technology Brisbane Queensland Australia

3. Department of Obstetrics and Gynecology, Division of Gynecologic Oncology University Hospitals KU Leuven, University of Leuven Leuven Belgium

4. Hunter Medical Research Institute John Hunter Hospital Newcastle New South Wales Australia

5. Centre for Information Based Medicine University of Newcastle Callaghan New South Wales Australia

6. Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health University of Newcastle Callaghan New South Wales Australia

7. Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health University of Newcastle Callaghan New South Wales Australia

8. Cancer Prevention Program Fred Hutchinson Cancer Research Center Seattle Washington USA

9. Zilber School of Public Health University of Wisconsin‐Milwaukee Milwaukee Wisconsin USA

10. Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER‐EMN University Hospital Erlangen, Friedrich‐Alexander‐University Erlangen‐Nuremberg Erlangen Germany

11. Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Maryland USA

12. Department of Clinical Pathology The University of Melbourne Melbourne Victoria Australia

13. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne Melbourne Victoria Australia

14. Genomic Medicine and Family Cancer Clinic Royal Melbourne Hospital Parkville Victoria Australia

15. University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre Parkville Victoria Australia

16. Department of Health and Human Services, Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health Bethesda Maryland USA

17. Epidemiology Program Fred Hutchinson Cancer Research Center Seattle Washington USA

18. Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts USA

19. Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre University of Oxford Oxford UK

20. University of New Mexico Health Sciences Center Albuquerque New Mexico USA

21. Department of Cancer Epidemiology and Prevention Research Alberta Health Services Calgary Alberta Canada

22. Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA

23. Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden

24. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care University of Cambridge Cambridge UK

25. Gynaecology Research Unit Hannover Medical School Hannover Germany

26. Department of Obstetrics and Gynecology, Division of Gynecologic Oncology Mayo Clinic Rochester Minnesota USA

27. Centre for Cancer Genetic Epidemiology, Department of Oncology University of Cambridge Cambridge UK

28. Department of Gynaecology Jena University Hospital ‐ Friedrich Schiller University Jena Germany

29. Institute of Human Genetics, University Hospital Erlangen, Friedrich‐Alexander University Erlangen‐Nuremberg, Comprehensive Cancer Center Erlangen‐EMN Erlangen Germany

30. David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology University of California at Los Angeles Los Angeles California USA

31. Department of Biostatistics Kansas University Medical Center Kansas City Kansas USA

32. Behavioral and Epidemiology Research Group American Cancer Society Atlanta Georgia USA

33. Cancer Epidemiology Division Cancer Council Victoria Melbourne Victoria Australia

34. Precision Medicine, School of Clinical Sciences at Monash Health Monash University Clayton Victoria Australia

35. Department of Health Science Research, Division of Epidemiology Mayo Clinic Rochester Minnesota USA

36. Department of Preventive Medicine, Keck School of Medicine University of Southern California Los Angeles California USA

37. Department of Oncology Södersjukhuset Stockholm Sweden

38. Department of Biostatistics & Epidemiology University of Massachusetts, Amherst Amherst Massachusetts USA

39. Department of Clinical Genetics St George's, University of London London UK

40. Centre for Cancer Biomarkers CCBIO, Department of Clinical Science University of Bergen Bergen Norway

41. Department of Obstetrics and Gynecology Haukeland University Hospital Bergen Norway

42. Program in Genetic Epidemiology and Statistical Genetics Harvard T.H. Chan School of Public Health Boston Massachusetts USA

43. Nuffield Department of Population Health University of Oxford Oxford UK

44. VIB Center for Cancer Biology Leuven Belgium

45. Laboratory for Translational Genetics, Department of Human Genetics University of Leuven Leuven Belgium

46. Epidemiology Program University of Hawaii Cancer Center Honolulu Hawaii USA

47. Department of Epidemiology and Biostatistics Memorial Sloan‐Kettering Cancer Center New York New York USA

48. Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden

49. Department of Clinical Genetics Karolinska University Hospital Stockholm Sweden

50. Department of Cancer Epidemiology and Prevention, M. Sklodowska‐Curie Cancer Center Oncology Institute Warsaw Poland

51. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt‐Ingram Cancer Center Vanderbilt University School of Medicine Nashville Tennessee USA

52. Chronic Disease Epidemiology Yale School of Medicine New Haven Connecticut USA

53. Department of Anatomic Pathology Moffitt Cancer Center & Research Institute Tampa Florida USA

54. Institute of Cancer and Genomic Sciences, University of Birmingham Birmingham UK

55. Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden

56. Department of Biochemistry and Molecular Medicine University of California Davis Davis California USA

57. School of Medicine and Public Health University of Newcastle Callaghan New South Wales Australia

58. Harvard T.H. Chan School of Public Health Boston Massachusetts USA

59. Dana‐Farber Cancer Institute Boston Massachusetts USA

60. Department of Gynaecology and Obstetrics University Hospital Erlangen, Friedrich‐Alexander University Erlangen‐Nuremberg, Comprehensive Cancer Center Erlangen‐EMN Erlangen Germany

61. Center for Cancer Prevention (CPO‐Peimonte) Turin Italy

62. Human Genetics Foundation (HuGeF) Turin Italy

63. Department of Obstetrics and Gynecology, School of Medicine and Public Health University of Wisconsin Madison Wisconsin USA

64. Department of Population and Quantitative Health Sciences Case Western Reserve University Cleveland Ohio USA

65. Division of Molecular Medicine, Pathology North John Hunter Hospital Newcastle New South Wales Australia

66. Clinical Genetics Karolinska Institutet Stockholm Sweden

67. State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai China

68. Population Health Department QIMR Berghofer Medical Research Institute Brisbane Queensland Australia

Funder

Fred Hutchinson Cancer Research Center

Susan G. Komen

Haukeland Universitetssjukehus

Mayo Foundation for Medical Education and Research

Cancer Council Tasmania

National Cancer Institute

National Heart, Lung, and Blood Institute

Ovarian Cancer Research Fund

Breast Cancer Research Foundation

Canadian Institutes of Health Research

Department of Defence, Australian Government

Foundation for the National Institutes of Health

Cancer Research UK

National Health and Medical Research Council

Publisher

Wiley

Subject

Cancer Research,Oncology

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