Imaging P‐Glycoprotein Function at the Blood–Brain Barrier as a Determinant of the Variability in Response to Central Nervous System Drugs-Reference-Cited by-同舟云学术

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Imaging P‐Glycoprotein Function at the Blood–Brain Barrier as a Determinant of the Variability in Response to Central Nervous System Drugs

Published:2019-03-23 Issue:5 Volume:105 Page:1061-1064
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Bauer Martin¹,Tournier Nicolas²,Langer Oliver¹³⁴

Affiliation:

1. Department of Clinical PharmacologyMedical University of Vienna Vienna Austria

2. UMR 1023 IMIVService Hospitalier Frédéric JoliotCEAInsermUniversité Paris SudCNRSUniversité Paris‐Saclay Orsay France

3. Preclinical Molecular ImagingAIT Austrian Institute of Technology GmbH Seibersdorf Austria

4. Division of Nuclear MedicineDepartment of Biomedical Imaging and Image‐Guided TherapyMedical University of Vienna Vienna Austria

Funder

Austrian Science Fund

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.1402

Reference10 articles.

1. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

2. Imaging the Function of P-Glycoprotein With Radiotracers: Pharmacokinetics and In Vivo Applications

3. Imaging techniques to study drug transporter function in vivo

4. Imaging of Cyclosporine Inhibition of P-Glycoprotein Activity Using 11C-Verapamil in the Brain: Studies of Healthy Humans

5. Why Clinical Modulation of Efflux Transport at the Human Blood–Brain Barrier Is Unlikely: The ITC Evidence-Based Position

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