A high-throughput inhibition screening of major human cytochrome P450 enzymes using anin vitrococktail and liquid chromatography-tandem mass spectrometry-Reference-Cited by-同舟云学术

A high-throughput inhibition screening of major human cytochrome P450 enzymes using anin vitrococktail and liquid chromatography-tandem mass spectrometry

Published:2013-08-15 Issue:2 Volume:28 Page:197-203
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomed. Chromatogr.

Author:

Qin Chong-Zhen¹,Ren Xian²,Tan Zhi-Rong¹,Chen Yao¹,Yin Ji-Ye¹,Yu Jing¹,Qu Jian¹,Zhou Hong-Hao¹,Liu Zhao-Qian¹

Affiliation:

1. Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics; Central South University Xiangya School of Medicine; Changsha Hunan 410078 People's Republic of China

2. Shanghai Green Valley Pharmaceutical Co. Ltd; Shanghai 201203 People's Republic of China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference38 articles.

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3. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions;Bertz;Clinical Pharmacokinetics,1997

4. A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes;Bhoopathy;Journal of Pharmacy and Biomedical Analysis,2005

5. High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and their metabolites;Bu;Rapid Communications in Mass Spectrometry,2000

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