Experimental evaluation of single‐domain antibodies predicted by molecular dynamics simulations to have elevated thermal stability
Author:
Affiliation:
1. Center for Biomolecular Science and EngineeringNaval Research Laboratory Washington District of Columbia
2. Systems and Structural Biology DivisionUSAMRIID Frederick Maryland
Publisher
Wiley
Subject
Molecular Biology,Biochemistry
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/pro.3692
Reference13 articles.
1. Enhancing Stability of Camelid and Shark Single Domain Antibodies: An Overview
2. Disulfide Bond Introduction for General Stabilization of Immunoglobulin Heavy-Chain Variable Domains
3. Evaluation of Disulfide Bond Position to Enhance the Thermal Stability of a Highly Stable Single Domain Antibody
4. Thermal stability of single‐domain antibodies estimated by molecular dynamics simulations
5. Facile Generation of Heat-Stable Antiviral and Antitoxin Single Domain Antibodies from a Semisynthetic Llama Library
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