T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-γ and is inhibited by transforming growth factor-β-Reference-Cited by-同舟云学术

T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-γ and is inhibited by transforming growth factor-β

Published:1994-04 Issue:4 Volume:24 Page:793-798
ISSN:0014-2980
Container-title:European Journal of Immunology
language:en
Short-container-title:Eur. J. Immunol.

Author:

Schmitt Edgar,Hoehn Petra,Huels Christoph,Goedert Sigrid,Palm Norbert,Rüde Erwin,Germann Tieno

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference40 articles.

1. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

2. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

3. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

4. Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

5. The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer

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