Co-receptor-independent signal transduction in a mismatched CD8+ major histocompatibility complex class II-specific allogeneic cytotoxic T lymphocyte
Author:
Publisher
Wiley
Subject
Immunology,Immunology and Allergy
Reference36 articles.
1. The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation
2. Substitution at residue 227 of H–2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes
3. Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule.
4. Antigen recognition by the T cell receptor is enhanced by CD8 α-chain binding to the α3 domain of MHC class I molecules, not by signaling via the cytoplasmic domain of CD8α
5. CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes
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