Polymer‐Protein Assemblies with Tunable Vesicular and Hierarchical Nanostructures

Author:

Ren Yingying1,Guan Shanyue2,Qu Xiaozhong1ORCID

Affiliation:

1. Center of Materials Science and Optoelectronics Engineering, College of Materials Science and Opto-Electronic Technology University of Chinese Academy of Sciences Beijing 101408 China

2. Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China

Abstract

AbstractThe construction of variable structured multi‐protein nano‐assemblies is of great interest for the development of protein‐based therapeutic systems. This study showcases the synthesis of polymer‐protein assemblies with tunable structure like single‐ and multi‐layer polymer‐crosslinked protein vesicles, Janus protein vesicles and other hierarchical‐structured assemblies by utilizing a dynamic template‐assistant intermittent‐assembly approach. The generalization of the methodology helps the protein assemblies to gain notable functional complexity. And we demonstrate compelling evidence highlighting the substantial impact of the topological morphology of protein nanoaggregates on their cellular uptake capacity.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Publisher

Wiley

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