Potent De Novo Macrocyclic Peptides That Inhibit O‐GlcNAc Transferase through an Allosteric Mechanism-Reference-Cited by-同舟云学术

Potent De Novo Macrocyclic Peptides That Inhibit O‐GlcNAc Transferase through an Allosteric Mechanism

Published:2022-12-27 Issue:5 Volume:62 Page:
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew Chem Int Ed

Author:

Alteen Matthew G.¹^ORCID,Peacock Hayden²^ORCID,Meek Richard W.³^ORCID,Busmann Jil A.⁴,Zhu Sha¹^ORCID,Davies Gideon J.³^ORCID,Suga Hiroaki²^ORCID,Vocadlo David J.¹⁴^ORCID

Affiliation:

1. Department of Chemistry Simon Fraser University Burnaby BC V5A 1S6 Canada

2. Department of Chemistry Graduate School of Science The University of Tokyo 7-3-1 Bunkyo-ku Tokyo 113-0033 Japan

3. York Structural Biology Laboratory Department of Chemistry University of York York YO10 5DD UK

4. Department of Molecular Biology and Biochemistry Simon Fraser University Burnaby BC V5A 1S6 Canada

Funder

Canadian Glycomics Network

Canadian Cancer Society Research Institute

Japan Society for the Promotion of Science

Canada Research Chairs

Canadian Institutes of Health Research

Royal Society

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202215671

Reference58 articles.

1. O-GlcNAcase Is an RNA Polymerase II Elongation Factor Coupled to Pausing Factors SPT5 and TIF1β

2. O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains

3. O-GlcNAcylation promotes cerebellum development and medulloblastoma oncogenesis via SHH signaling

4. Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism

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