Modular Halogenation, α‐Hydroxylation, and Acylation by a Remarkably Versatile Polyketide Synthase-Reference-Cited by-同舟云学术

Modular Halogenation, α‐Hydroxylation, and Acylation by a Remarkably Versatile Polyketide Synthase

Published:2022-01-27 Issue:11 Volume:61 Page:
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew Chem Int Ed

Author:

Hemmerling Franziska¹,Meoded Roy A.¹,Fraley Amy E.¹,Minas Hannah A.¹,Dieterich Cora L.¹,Rust Michael¹,Ueoka Reiko¹²,Jensen Katja¹,Helfrich Eric J. N.¹³⁴,Bergande Cedric¹,Biedermann Maurice¹,Magnus Nancy⁵,Piechulla Birgit⁵,Piel Jörn¹^ORCID

Affiliation:

1. Institute of Microbiology Eidgenössische Technische Hochschule (ETH) Zurich Vladimir-Prelog-Weg 4 8093 Zurich Switzerland

2. School of Marine Bioscience Kitasato University 1-15-1, Kitazato, Minami-ku Sagamirhara-shi Kanagawa 252-0373 Japan

3. Institute of Molecular Bio Science Goethe University Frankfurt Max-von-Laue-Str. 9 60438 Frankfurt am Main Germany

4. LOEWE Center for Translational Biodiversity Genomics (TBG) Senckenberganlage 25 60325 Frankfurt am Main Germany

5. Institute for Biological Sciences University of Rostock Albert-Einstein-Straße 3 18059 Rostock Germany

Funder

H2020 European Research Council

Gordon and Betty Moore Foundation

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202116614

Reference59 articles.

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2. The structural biology of biosynthetic megaenzymes

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4. The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

5. Biosynthesis of polyketides by trans-AT polyketide synthases

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