Affiliation:
1. Department of Chemical Sciences University of Padua Via Marzolo1 35131 Padua Italy
Abstract
AbstractAn energy ratchet mechanism is exploited for the synthesis of a molecule. In the presence of adenosine triphosphate (ATP), hydrazone‐bond formation between an aldehyde and hydrazide is accelerated and the composition at thermodynamic equilibrium is shifted towards the hydrazone. Enzymatic hydrolysis of ATP installs a kinetically stable state, at which hydrazone is present at a higher concentration compared to the composition at thermodynamic equilibrium in the presence of the degradation products of ATP. It is shown that the kinetic state has an enhanced catalytic activity in the hydrolysis of an RNA‐model compound.
Funder
Ministero dell’Istruzione, dell’Università e della Ricerca
Università degli Studi di Padova
Subject
General Chemistry,Catalysis
Cited by
4 articles.
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