A Dual‐Metal‐Catalyzed Sequential Cascade Reaction in an Engineered Protein Cage**

Author:

Ebensperger Paul1,Zmyslia Mariia1,Lohner Philipp1,Braunreuther Judith1,Deuringer Benedikt2,Becherer Anita3,Süss Regine2,Fischer Anna3,Jessen‐Trefzer Claudia1ORCID

Affiliation:

1. Institute of Organic Chemistry University of Freiburg Alberstrasse 21 79104 Freiburg i. Br. Germany

2. Institute of Pharmaceutical Science University of Freiburg Sonnenstrasse 5 79104 Freiburg i. Br. Germany

3. Institute of Inorganic and Analytical Chemistry University of Freiburg Alberstrasse 21 79104 Freiburg i. Br. Germany

Abstract

AbstractHerein, we describe the creation of an artificial protein cage housing a dual‐metal‐tagged guest protein that catalyzes a linear, two‐step sequential cascade reaction. The guest protein consists of a fusion protein of HaloTag and monomeric rhizavidin. Inside the protein capsid, we established a ruthenium‐catalyzed allylcarbamate deprotection reaction followed by a gold‐catalyzed ring‐closing hydroamination reaction that led to indoles and phenanthridines with an overall yield of up to 66 % in aqueous solutions. Furthermore, we show that the encapsulation stabilizes the metal catalysts against deactivation by air, proteins and cell lysate.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

General Chemistry,Catalysis

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