Directed Evolution of a Halide Methyltransferase Enables Biocatalytic Synthesis of Diverse SAM Analogs-Reference-Cited by-同舟云学术

Directed Evolution of a Halide Methyltransferase Enables Biocatalytic Synthesis of Diverse SAM Analogs

Published:2020-11-12 Issue:3 Volume:60 Page:1524-1527
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Tang Qingyun¹^ORCID,Grathwol Christoph W.²^ORCID,Aslan‐Üzel Aşkın S.¹^ORCID,Wu Shuke¹^ORCID,Link Andreas²^ORCID,Pavlidis Ioannis V.³^ORCID,Badenhorst Christoffel P. S.¹^ORCID,Bornscheuer Uwe T.¹^ORCID

Affiliation:

1. Institute of Biochemistry University of Greifswald Felix-Hausdorff-Strasse 4 17489 Greifswald Germany

2. Institute of Pharmacy University of Greifswald Friedrich-Ludwig-Jahn-Strasse 17 17489 Greifswald Germany

3. Department of Chemistry University of Crete Voutes University Campus 70013 Heraklion Greece

Funder

China Scholarship Council

Horizon 2020 Framework Programme

Alexander von Humboldt-Stiftung

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202013871

Reference46 articles.

2. Profound Methyl Effects in Drug Discovery and a Call for New CH Methylation Reactions

3. Ausgeprägte Methyleffekte in der Wirkstoff-Forschung und der Bedarf an neuen C-H-Methylierungsreaktionen

4. The Methylation Effect in Medicinal Chemistry

5. Challenging nature’s preference for methylation

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