Affiliation:
1. Latvian Institute of Organic Synthesis Aizkraukles iela 21 LV-1006 Riga Latvia
2. Institute of Food Safety, Animal Health and Environment “BIOR” Lejupes iela 3 LV-1076 Riga Latvia
Abstract
AbstractA simple process for the oxy‐monofluoromethylation of alkenes is described. In combination with visible‐light copper(I) photoredox catalysis, an easily accessible iodine(III) reagent containing monofluoroacetoxy ligands serves as a powerful source of a monofluoromethyl (CH2F) radical, enabling the step economical synthesis of γ‐fluoro‐acetates from a broad range of olefinic substrates under mild conditions. Applications to late‐stage diversification of alkenes derived from complex molecules, amino acids and the synthesis of fluoromethylated heterocycles are also demonstrated.
Funder
European Regional Development Fund
Subject
General Chemistry,Catalysis
Cited by
6 articles.
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