Affiliation:
1. Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education School of Chemical Science and Technology Yunnan Provincial Center for Research & Development of Natural Products State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan University Kunming 650091 China
2. School of Life Sciences Yunnan University Kunming 650091 China
Abstract
AbstractA method for the asymmetric construction of functionalized acyclic all‐carbon quaternary stereocenters and 1,3‐nonadjacent stereoelements has been developed via organo/metal dual catalyzed asymmetric allenylic substitution of branched and linear aldehydes, by developing an unknown acyclic secondary‐secondary diamine as the enabling organocatalyst. Although it is believed that secondary‐secondary diamines are difficult to be used as the organocatalysts in organo/metal dual catalysis, this study demonstrates that such diamines can be successfully combined with a metal catalyst in organo/metal dual catalysis. Our study enables the asymmetric construction of two important classes of motifs which were previously difficult to access, axially chiral allene‐containing acyclic all‐carbon quaternary stereocenters and 1,3‐nonadjacent stereoelements bearing allenyl axial chirality and central chirality, in good yields with high enantio‐ and diastereoselectivity.
Subject
General Chemistry,Catalysis
Cited by
7 articles.
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