Affiliation:
1. Key Laboratory of Agri-Food Safety of Anhui Province, School of Resources and Environment,Anhui Agricultural University Hefei Anhui 230036 China
Abstract
AbstractIn this study, we designed a bilateral disulfurating reagent via S−S motif “snip and stitch” processes, allowing diverse functional groups to be bridged via S−S bonds. The reagent is readily synthesized in high yield using a one‐step reaction from easily available starting materials and is air‐stable. With this reagent, diverse electrophiles including inactivated alkyl Cl/Br/I/OMs and benzyl chloride were sequentially installed on either side of the S−S motif. Natural products, agrochemicals, and pharmaceuticals can be successively cross‐linked with S−S bonds. Notably, the disulfurating reagent can be used in cyclic disulfide synthesis. At last, some desired products of this work showed good antibacterial activities, which could be employed as novel candidates to control plant pathogenic bacteria.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Natural Science Foundation of Anhui Province
Subject
General Chemistry,Catalysis
Cited by
7 articles.
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