The Active Site of a Prototypical “Rigid” Drug Target is Marked by Extensive Conformational Dynamics-Reference-Cited by-同舟云学术

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The Active Site of a Prototypical “Rigid” Drug Target is Marked by Extensive Conformational Dynamics

Published:2020-11-16 Issue:51 Volume:59 Page:22916-22921
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Singh Himanshu¹²^ORCID,Das Chandan K.³,Vasa Suresh K.¹²^ORCID,Grohe Kristof¹²,Schäfer Lars V.³^ORCID,Linser Rasmus¹²^ORCID

Affiliation:

1. Faculty of Chemistry and Chemical Biology Technical University Dortmund Otto-Hahn-Str. 4a 44227 Dortmund Germany

2. Faculty for Chemistry and Pharmacy Ludwig-Maximilians-University Munich Butenandtstr. 5–13 81377 Munich Germany

3. Theoretical Chemistry Ruhr University Bochum Universitätsstr. 150 44801 Bochum Germany

Funder

Deutsche Forschungsgemeinschaft

H2020 European Research Council

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202009348

Reference34 articles.

1. Neutron Structure of Human Carbonic Anhydrase II: A Hydrogen-Bonded Water Network “Switch” Is Observed between pH 7.8 and 10.0

2. Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency

3. Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency

4. PDBFlex: exploring flexibility in protein structures

5.

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1. H, 15 N and 13 C resonance assignments of S2A and H64A double mutant of human carbonic anhydrase II;2024-07-10

2. 1H, 15N and13C resonance assignments of S2A mutant of human carbonic anhydrase II;Biomolecular NMR Assignments;2024-03-23

3. Allostery at a protein-protein interface harboring an intermolecular dynamic network;2024-01-08

4. Microsecond Timescale Conformational Dynamics of a Small‐Molecule Ligand within the Active Site of a Protein;Angewandte Chemie International Edition;2023-12-15

5. Konformationeller Austausch eines Liganden in der Bindetasche eines Proteins auf der Mikrosekundenzeitskala;Angewandte Chemie;2023-12-15

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