Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles-Reference-Cited by-同舟云学术

Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles

Published:2023-02-14 Issue:17 Volume:62 Page:
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew Chem Int Ed

Author:

Xie Maomao¹,Gao Meng¹^ORCID,Yun Yang²,Malmsten Martin³⁴^ORCID,Rotello Vincent M.⁵^ORCID,Zboril Radek⁶⁷^ORCID,Akhavan Omid⁸^ORCID,Kraskouski Aliaksandr⁹^ORCID,Amalraj John¹⁰^ORCID,Cai Xiaoming¹¹,Lu Jianmei¹²^ORCID,Zheng Huizhen¹^ORCID,Li Ruibin¹^ORCID

Affiliation:

1. State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou Medical College Soochow University Suzhou 215123 Jiangsu China

2. College of Environmental & Resource Sciences Shanxi University Taiyuan 030006 Shanxi China

3. Department of Pharmacy University of Copenhagen 2100 Copenhagen Denmark

4. Department of Physical Chemistry 1 University of Lund 22100 Lund Sweden

5. Department of Chemistry University of Massachusetts Amherst 710 N. Pleasant St. Amherst USA

6. Regional Centre of Advanced Technologies and Materials Czech Advanced Technology and Research Institute (CATRIN) Palacký University Olomouc Šlechtitelů 241/27 Olomouc 783 71 Czech Republic

7. Nanotechnology Centre Centre of Energy and Environmental Technologies VŠB-Technical University of Ostrava 17. listopadu 2172/15 Ostrava-Poruba 708 00 Czech Republic

8. Condensed Matter National Laboratory P.O. Box 1956838861 Tehran Iran

9. Department of Physicochemistry of Thin Film Materials Institute of Chemistry of New Materials of NAS of Belarus 36 F. Skaryna Str. 220084 Minsk Belarus

10. Laboratory of Materials Science Instituto de Química de Recursos Naturales Universidad de Talca P.O. Box 747 Talca Chile

11. School of Public Health Suzhou Medical College Soochow University Suzhou Jiangsu 215123 China

12. College of Chemistry Chemical Engineering and Materials Science National Center for International Research on Intelligent Nano-Materials and Detection Technology in Environmental Protection Soochow University Suzhou 215123 China

Abstract

AbstractAntimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR‐independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure‐activity relationships of antibiotics and antimicrobial nanomaterials. We then focus on nano‐microbe interactions to elucidate the impacts of molecular initiating events on AMR evolution. Finally, we provide an outlook on future antimicrobial nanomaterials and propose design principles for the prevention of AMR evolution.

Funder

National Key Research and Development Program of China

Natural Science Foundation of Jiangsu Province

Mission on Nano Science and Technology

National Institutes of Health

LEO Fondet

Vetenskapsrådet

Publisher

Wiley

Subject

General Chemistry,Catalysis

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