Drug‐Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side‐Chain Lipophilicity-Reference-Cited by-同舟云学术

Drug‐Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side‐Chain Lipophilicity

Published:2020-09-17 Issue:48 Volume:59 Page:21571-21577
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Furukawa Akihiro¹,Schwochert Joshua²,Pye Cameron R.²,Asano Daigo¹,Edmondson Quinn D.³,Turmon Alexandra C.²,Klein Victoria G.⁴,Ono Satoshi⁵,Okada Okimasa⁵,Lokey R. Scott⁴^ORCID

Affiliation:

1. Daiichi Sankyo Co., Ltd. 1-2-58, Hiromachi, Shinagawa-ku Tokyo 140-8710 Japan

2. Unnatural Products, Inc. 250 Natural Bridges Drive Santa Cruz CA 95060 USA

3. Department of Pharmaceutical Chemistry University of California, San Francisco San Francisco California 94158 USA

4. Department of Chemistry & Biochemistry University of California Santa Cruz Santa Cruz CA 96064 USA

5. Discovery Technology Laboratories Mitsubishi Tanabe Pharma Corporation Yokohama 227-0033 Japan

Funder

National Institute of General Medical Sciences

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202004550

Reference59 articles.

2. How many drug targets are there?

3. Analysis of the Human Endogenous Coregulator Complexome

5. Selection-Based Discovery of Druglike Macrocyclic Peptides

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