Affiliation:
1. State Key Laboratory and Institute of Elemento-Organic Chemistry College of Chemistry Nankai University Tianjin 300071 China
Abstract
AbstractDue to the strong electron‐withdrawing nature and high lipophilicity of trifluoromethoxy group (OCF3), methods for introducing OCF3into organic molecules are in high demand. However, the research area of direct enantioselective trifluoromethoxylation is still in the embryonic stage, with limited enantioselectivity and/or reaction types. Here, we describe the first copper‐catalyzed enantioselective trifluoromethoxylation of propargyl sulfonates using trifluoromethyl arylsulfonate (TFMS) as the trifluoromethoxy source in up to 96 % ee.
Funder
National Natural Science Foundation of China
Subject
General Chemistry,Catalysis
Cited by
11 articles.
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