Electrocatalytic Synthesis of Pyridine Oximes using in Situ Generated NH2OH from NO species on Nanofiber Membranes Derived from NH2‐MIL‐53(Al)

Author:

Xiang Runan1,Wang Shihan1,Liao Peisen1,Xie Fangyan2,Kang Jiawei1,Li Suisheng1,Xian Jiahui1,Guo Linna2,Li Guangqin1ORCID

Affiliation:

1. Key Laboratory of Bioinorganicand Synthetic Chemistry of Ministry of Education LIFM IGCME School of Chemistry Sun Yat-Sen University Guangzhou 510006 China

2. Instrumental Analysis & Research Center Sun Yat-Sen University No.135, Xingangxi Road Guangzhou 510275 China

Abstract

AbstractPyridine oximes produced from aldehyde or ketone with hydroxylamine (NH2OH) have been widely applied in pharmaceutics, enzymatic and sterilization. However, the important raw material NH2OH exhibits corrosive and unstable properties, leading to substantial energy consumption during storage and transportation. Herein, this work presents a novel method for directly synthesizing highly valuable pyridine oximes using in situ generated NH2OH from electrocatalytic NO reduction with well‐design nanofiber membranes (Al‐NFM) derived from NH2‐MIL‐53(Al). Particularly, 2‐pyridinealdoxime, the precursor of antidote pralidoxime (2‐PAM) for nerve agents suffering from scarcity and high cost, was achieved with a Faraday efficiency up to 49.8 % and a yield of 92.1 %, attributing to the high selectivity of NH2OH production on Al‐NFM, further easily reacted with iodomethane to produce 2‐PAM. This study proposes a creative approach, having wide universality for synthesizing pyridine and other oximes with a range of functional groups, which not only facilitates the conversion of exhaust gas (NO) and waste water (NO2) into valuable chemicals especially NH2OH production and in situ utilization through electrochemistry, but also holds significant potential for synthesis of neuro detoxifying drugs to humanity security.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Chemistry,Catalysis

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3