Affiliation:
1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry and Chemical Engineering Center for Advanced Low-dimension Materials Donghua University Shanghai 201620 China
Abstract
AbstractA Markovnikov‐selective hydrodifluoromethylation of alkynes with BrCF2H via nickel catalysis is described. This protocol proceeds via a migratory insertion of nickel hydride to alkyne followed by a CF2H‐coupling, enabling straightforward access to diverse branched CF2H‐alkenes with high efficiency and exclusive regioselectivity. The mild condition applies to a wide array of aliphatic and aryl alkynes with good functional group compatibility. Mechanistic studies are presented to support the proposed pathway.
Funder
National Natural Science Foundation of China
Subject
General Chemistry,Catalysis
Cited by
7 articles.
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