An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the Pt II Linker Lx for Improved Manufacturability of Antibody

An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the Pt II Linker Lx for Improved Manufacturability of Antibody–Drug Conjugates

Published:2021-01-15 Issue:6 Volume:60 Page:3008-3015
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Merkul Eugen¹^ORCID,Muns Joey A.¹,Sijbrandi Niels J.¹,Houthoff Hendrik‐Jan¹,Nijmeijer Bart¹,Rheenen Gerro¹,Reedijk Jan²,Dongen Guus A. M. S.³

Affiliation:

1. Chemistry Department LinXis BV De Boelelaan 1085c Amsterdam 1081 HV The Netherlands

2. Leiden Institute of Chemistry Leiden University PO Box 9502 2300 RA Leiden The Netherlands

3. Department of Radiology and Nuclear Medicine Amsterdam UMC, location VU medical center Amsterdam The Netherlands

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202011593

Reference67 articles.

1. The Role of Organic Synthesis in the Emergence and Development of Antibody–Drug Conjugates as Targeted Cancer Therapies

3. Antibody–Drug Conjugates: The Last Decade

4. Antibody-Drug Conjugates: The New Frontier of Chemotherapy

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