Mass Spectrometry Detection and Imaging of a Non‐Covalent Protein–Drug Complex in Tissue from Orally Dosed Rats-Reference-Cited by-同舟云学术

Mass Spectrometry Detection and Imaging of a Non‐Covalent Protein–Drug Complex in Tissue from Orally Dosed Rats

Published:2022-07-13 Issue:36 Volume:61 Page:
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew Chem Int Ed

Author:

Illes‐Toth Eva¹^ORCID,Hale Oliver J.¹^ORCID,Hughes James W.¹^ORCID,Strittmatter Nicole²^ORCID,Rose Jonathan³,Clayton Ben³,Sargeant Rebecca²,Jones Stewart²,Dannhorn Andreas²,Goodwin Richard J. A.²^ORCID,Cooper Helen J.¹^ORCID

Affiliation:

1. School of Biosciences University of Birmingham Edgbaston Birmingham B15 2TT UK

2. Imaging & Data Analytics Clinical Pharmacology & Safety Sciences Biopharmaceuticals R&D, AstraZeneca Cambridge CB4 0WG UK

3. Animal Sciences & Technologies Clinical Pharmacology & Safety Sciences, AstraZeneca Babraham Research Campus Babraham Cambridge, CB22 3AT UK

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202202075

Reference29 articles.

2. Direct Mass Spectrometry Analysis of Protein Complexes and Intact Proteins up to >70 kDa from Tissue

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4. Native Mass Spectrometry Imaging of Proteins and Protein Complexes by Nano-DESI

5. Native Ambient Mass Spectrometry Enables Analysis of Intact Endogenous Protein Assemblies up to 145 kDa Directly from Tissue

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