Supramolecular Cylinders Target Bulge Structures in the 5′ UTR of the RNA Genome of SARS‐CoV‐2 and Inhibit Viral Replication**-Reference-Cited by-同舟云学术

Supramolecular Cylinders Target Bulge Structures in the 5′ UTR of the RNA Genome of SARS‐CoV‐2 and Inhibit Viral Replication**

Published:2021-07-09 Issue:33 Volume:60 Page:18144-18151
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Melidis Lazaros¹^ORCID,Hill Harriet J.²^ORCID,Coltman Nicholas J.³^ORCID,Davies Scott P.²^ORCID,Winczura Kinga³^ORCID,Chauhan Tasha¹,Craig James S.¹^ORCID,Garai Aditya⁴^ORCID,Hooper Catherine A. J.⁴,Egan Ross T.⁴^ORCID,McKeating Jane A.⁵^ORCID,Hodges Nikolas J.³^ORCID,Stamataki Zania²^ORCID,Grzechnik Pawel³^ORCID,Hannon Michael J.¹⁴^ORCID

Affiliation:

1. Physical Sciences for Health Centre University of Birmingham Edgbaston Birmingham B15 2TT UK

2. Institute of Immunology and Immunotherapy University of Birmingham Edgbaston Birmingham B15 2TT UK

3. School of Biosciences University of Birmingham Edgbaston Birmingham B15 2TT UK

4. School of Chemistry University of Birmingham Edgbaston Birmingham B15 2TT UK

5. Nuffield Department of Medicine & Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI) Oxford University Oxford OX3 7BN UK

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Wellcome Trust

Medical Research Council

Royal Perth Hospital Medical Research Foundation

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202104179

Reference85 articles.

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2. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters

3. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

4. Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites

5. Favipiravir (T-705), a novel viral RNA polymerase inhibitor

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