Aryne‐Enabled C−N Arylation of Anilines-Reference-Cited by-同舟云学术

Aryne‐Enabled C−N Arylation of Anilines

Published:2023-11-06 Issue:49 Volume:62 Page:
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew Chem Int Ed

Author:

Sephton Thomas¹^ORCID,Charitou Anastasios¹^ORCID,Trujillo Cristina¹^ORCID,Large Jonathan M.²,Butterworth Sam³^ORCID,Greaney Michael F.¹^ORCID

Affiliation:

1. School of Chemistry University of Manchester Manchester M13 9PL UK

2. LifeArc, Accelerator Building Open Innovation Campus Stevenage SG1 2FX UK

3. Division of Pharmacy and Optometry, School of Health Sciences, Manchester Academic Health Sciences Centre University of Manchester Manchester M13 9PL UK

Abstract

AbstractAnilines are potentially high‐value arylating agents, but are limited by the low reactivity of the strong C−N bond. We show that the reactive intermediate benzyne can be used to both activate anilines, and set‐up an aryl transfer reaction in a single step. The reaction does not require any transition metal catalysts or stoichiometric organometallics, and establishes a metal‐free route to valuable biaryl products by functionalizing the aniline C−N bond.

Funder

Engineering and Physical Sciences Research Council

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202310583

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