Single‐Crystal‐to‐Single‐Crystal Topochemical Synthesis of a Collagen‐inspired Covalent Helical Polymer

Author:

Rai Rishika1ORCID,Khazeber Ravichandran1ORCID,Sureshan Kana M1ORCID

Affiliation:

1. School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram Thiruvananthapuram Kerala 695551 India

Abstract

AbstractThere is much demand for crystalline covalent helical polymers. Inspired by the helical structure of collagen, we synthesized a covalent helical polymer wherein the repeating dipeptide Gly‐Pro units are connected by triazole linkages. We synthesized an azide and alkyne‐modified dipeptide monomer made up of the repeating amino acid sequence of collagen. In its crystals, the monomer molecules aligned in head‐to‐tail fashion with proximally placed azide and alkyne forming supramolecular helices. At 60 °C, the monomer underwent single‐crystal‐to‐single‐crystal (SCSC) topochemical azide‐alkyne cycloaddition polymerization, yielding a covalent helical polymer as confirmed by single‐crystal X‐ray diffraction (SCXRD) analysis. Compared to the monomer crystals, the polymer single‐crystals were very strong and showed three‐fold increase in Young's modulus, which is higher than collagen, many synthetic polymers and other materials. The crystals of this covalent helical polymer could bear loads as high as 1.5 million times of their own weight without deformation. These crystals could also withstand high compression force and did not disintegrate even at an applied force of 98 kN. Such light‐weight strong materials are in demand for various technological applications.

Funder

Science and Engineering Research Board

Publisher

Wiley

Subject

General Chemistry,Catalysis

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