Novel β‐Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization-Reference-Cited by-同舟云学术

Novel β‐Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization

Published:2021-01-19 Issue:10 Volume:60 Page:5436-5442
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Benz Joerg¹^ORCID,Rufer Arne C.¹,Huber Sylwia¹,Ehler Andreas¹,Hug Melanie¹,Topp Andreas¹,Guba Wolfgang²,Hofmann Eva Carolina³,Jagasia Ravi⁴,Rodríguez Sarmiento Rosa María⁵^ORCID

Affiliation:

1. Lead Discovery Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland

2. CADD Roche Innovation Center Basel Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland

3. Roche Pharma Research and Early Development Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland

4. NRD Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland

5. Medicinal Chemistry Roche Pharma Research and Early Development (pRED) Roche Innovation Center Basel F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202013890

Reference62 articles.

2. Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA)

3. A Review of Gaucher Disease Pathophysiology, Clinical Presentation and Treatments

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