Tuning Local Coordination Environments of Manganese Single‐Atom Nanozymes with Multi‐Enzyme Properties for Selective Colorimetric Biosensing

Author:

Wang Ying1ORCID,Cho Ara1,Jia Guangri2ORCID,Cui Xiaoqiang2ORCID,Shin Junhyeop3,Nam Inho3,Noh Kyung‐Jong1ORCID,Park Byoung Joon1,Huang Rui1ORCID,Han Jeong Woo1ORCID

Affiliation:

1. Department of Chemical Engineering Pohang University of Science and Technology (POSTECH) Pohang, Gyeongbuk 37673 (Republic of Korea

2. State Key Laboratory of Automotive Simulation and Control School of Materials Science and Engineering Key Laboratory of Automobile Materials of MOE Jilin University Changchun Jilin 130012 China

3. School of Chemical Engineering and Materials Science Department of Intelligent Energy and Industry Institute of Energy Converting Soft Materials Chung-Ang University Seoul 06974 (Republic of Korea

Abstract

AbstractSingle‐atom nanozymes (SAzymes) are promising in next‐generation nanozymes, nevertheless, how to rationally modulate the microenvironment of SAzymes with controllable multi‐enzyme properties is still challenging. Herein, we systematically investigate the relationship between atomic configuration and multi‐enzymatic performances. The constructed MnSA−N3‐coordinated SAzymes (MnSA−N3−C) exhibits much more remarkable oxidase‐, peroxidase‐, and glutathione oxidase‐like activities than that of MnSA−N4−C. Based on experimental and theoretical results, these multi‐enzyme‐like behaviors are highly dependent on the coordination number of single atomic Mn sites by local charge polarization. As a consequence, a series of colorimetric biosensing platforms based on MnSA−N3−C SAzymes is successfully built for specific recognition of biological molecules. These findings provide atomic‐level insight into the microenvironment of nanozymes, promoting rational design of other demanding biocatalysts.

Funder

National Research Foundation of Korea

Publisher

Wiley

Subject

General Chemistry,Catalysis

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