Affiliation:
1. School of Life Sciences Shanghai University Shanghai 200444 P. R. China
2. School of Environmental and Chemical Engineering Shanghai University Shanghai 200444 P. R. China
3. International Cooperation Laboratory of Molecular Medicine Academy of Chinese Medical Sciences Zhejiang Chinese Medical University Hangzhou 310053 P. R. China
4. School of Agriculture and Bioengineering Heze University Heze 274015 P. R. China
5. Shaoxing Institute of Shanghai University Shaoxing 312074 P. R. China
Abstract
AbstractHypertension, as a leading risk factor for cardiovascular diseases, is associated with oxidative stress and impairment of endogenous antioxidant mechanisms, but there is still a tremendous knowledge gap between hypertension treatment and nanomedicines. Herein, we report a specific nanozyme based on ultrathin two‐dimensional (2D) niobium carbide (Nb2C) MXene, termed Nb2C MXenzyme, to fight against hypertension by achieving highly efficient reactive oxygen species elimination and inflammatory factors inhibition. The biocompatible Nb2C MXenzyme displays multiple enzyme‐mimicking activities, involving superoxide dismutase, catalase, glutathione peroxidase, and peroxidase, inducing cytoprotective effects by resisting oxidative stress, thereby alleviating inflammatory response and reducing blood pressure, which is systematically demonstrated in a stress‐induced hypertension rat model. This strategy not only opens new opportunities for nanozymes to treat hypertension but also expands the potential biomedical applications of 2D MXene nanosystems.
Funder
Shanghai Shuguang Program
National Natural Science Foundation of China
Natural Science Foundation of Shandong Province
Subject
General Chemistry,Catalysis
Cited by
3 articles.
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