Enzymatic C4‐Epimerization of UDP‐Glucuronic Acid: Precisely Steered Rotation of a Transient 4‐Keto Intermediate for an Inverted Reaction without Decarboxylation-Reference-Cited by-同舟云学术

Enzymatic C4‐Epimerization of UDP‐Glucuronic Acid: Precisely Steered Rotation of a Transient 4‐Keto Intermediate for an Inverted Reaction without Decarboxylation

Published:2022-12-15 Issue:4 Volume:62 Page:
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew Chem Int Ed

Author:

Borg Annika J. E.¹^ORCID,Esquivias Oriol²^ORCID,Coines Joan²³^ORCID,Rovira Carme²⁴^ORCID,Nidetzky Bernd¹⁵^ORCID

Affiliation:

1. Institute of Biotechnology and Biochemical Engineering Graz University of Technology Petersgasse 12/1 8010 Graz Austria

2. Department of Inorganic and Organic Chemistry (Section of Organic Chemistry) Institute of Computational and Theoretical Chemistry (IQTCUB) Martí i Franquès 1 08028 Barcelona Spain

3. Present address: Nostrum Biodiscovery Av. De Josep Tarradellas, 8–10 08029 Barcelona Spain

4. Institució Catalana de Recerca i Estudis Avançats (ICREA) Passeig Lluís Companys, 23 08010 Barcelona Spain

5. Austrian Center of Industrial Biotechnology (acib) Krenngasse 37 8010 Graz Austria

Funder

Austrian Science Fund

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202211937

Reference45 articles.

2. The Depth of Chemical Time and the Power of Enzymes as Catalysts

3. Benchmark Reaction Rates, the Stability of Biological Molecules in Water, and the Evolution of Catalytic Power in Enzymes

5. Protein Flexibility and Stiffness Enable Efficient Enzymatic Catalysis

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1. Molecular Mechanism of Double-Displacement Retaining β-Kdo Glycosyltransferase WbbB;The Journal of Physical Chemistry B;2024-07-25

2. Interplay of structural preorganization and conformational sampling in UDP-glucuronic acid 4-epimerase catalysis;Nature Communications;2024-05-08