Degradable Block Copolymer Nanoparticles Synthesized by Polymerization‐Induced Self‐Assembly

Author:

Zhang Shudi1,Li Ruoyu1,An Zesheng12ORCID

Affiliation:

1. State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 China

2. Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life Sciences Jilin University Changchun 130012 China

Abstract

AbstractPolymerization‐induced self‐assembly (PISA) combines polymerization and in situ self‐assembly of block copolymers in one system and has become a widely used method to prepare block copolymer nanoparticles at high concentrations. The persistence of polymers in the environment poses a huge threat to the ecosystem and represents a significant waste of resources. There is an urgent need to develop novel chemical approaches to synthesize degradable polymers. To meet with this demand, it is crucial to install degradability into PISA nanoparticles. Most recently, degradable PISA nanoparticles have been synthesized by introducing degradation mechanisms into either shell‐forming or core‐forming blocks. This Minireview summarizes the development in degradable block copolymer nanoparticles synthesized by PISA, including shell‐degradable, core‐degradable, and all‐degradable nanoparticles. Future development will benefit from expansion of polymerization techniques with new degradation mechanisms and adaptation of high‐throughput approaches for both PISA syntheses and degradation studies.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Chemistry,Catalysis

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