Affiliation:
1. School of Petrochemical Engineering Changzhou University Changzhou 213164 China
2. School of Chemistry and Materials Science Jiangsu Normal University Xuzhou 221116 China
3. School of Chemistry and Chemical Engineering Henan Normal University Xinxiang 453007 China
Abstract
AbstractWith the rapid development of asymmetric catalysis, the demand for the enantioselective synthesis of complex and diverse molecules with different chiral elements is increasing. Owing to the unique features of atropisomerism, the catalytic asymmetric synthesis of atropisomers has attracted a considerable interest from the chemical science community. In particular, introducing additional chiral elements, such as carbon centered chirality, heteroatomic chirality, planar chirality, and helical chirality, into atropisomers provides an opportunity to incorporate new properties into axially chiral compounds, thus expanding the potential applications of atropisomers. Thus, it is important to perform catalytic asymmetric transformations to synthesize atropisomers bearing multiple chiral elements. In spite of challenges in such transformations, in recent years, chemists have devised powerful strategies under asymmetric organocatalysis or metal catalysis, synthesizing a wide range of enantioenriched atropisomers bearing multiple chiral elements. Therefore, the catalytic asymmetric synthesis of atropisomers bearing multiple chiral elements has become an emerging field. This review summarizes the rapid progress in this field and indicates challenges, thereby promoting this field to a new horizon.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
Subject
General Chemistry,Catalysis
Cited by
3 articles.
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