Tailorable and Biocompatible Supramolecular‐Based Hydrogels Featuring two Dynamic Covalent Chemistries

Abstract

AbstractDynamic covalent chemistry (DCC) has proven to be a valuable tool in creating fascinating molecules, structures, and emergent properties in fully synthetic systems. Here we report a system that uses two dynamic covalent bonds in tandem, namely disulfides and hydrazones, for the formation of hydrogels containing biologically relevant ligands. The reversibility of disulfide bonds allows fiber formation upon oxidation of dithiol‐peptide building block, while the reaction between NH−NH2 functionalized C‐terminus and aldehyde cross‐linkers results in a gel. The same bond‐forming reaction was exploited for the “decoration” of the supramolecular assemblies by cell‐adhesion‐promoting sequences (RGD and LDV). Fast triggered gelation, cytocompatibility and ability to “on‐demand” chemically customize fibrillar scaffold offer potential for applying these systems as a bioactive platform for cell culture and tissue engineering.