Foldaxane‐Based Switchable [c2]Daisy Chains

Author:

Liao Sibei1,Tang Jie1,Ma Chunmiao1,Yu Lu1,Tan Ying2,Li Xuanzhu1,Gan Quan1ORCID

Affiliation:

1. Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medical Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Luoyu Road No. 1037 430074 Wuhan China

2. State Key Laboratory of Chemical Oncogenomics Key Laboratory of Chemical Biology Tsinghua Shenzhen International Graduate School Tsinghua University 518055 Shenzhen China

Abstract

AbstractArtificial molecular muscles are highly attractive in the field of molecular machinery due to their unique properties of contraction and stretching motion. However, the synthesis of molecular muscles poses formidable challenges as it is hindered by undesirable yields and poor selectivity. Herein, we present a procedure for the dynamic assembly of foldaxane‐based [c2]daisy chains, wherein the hermaphroditic sequences consisting of aromatic helices and peptide rods are interlocked through inter‐strand hydrogen‐bonding interactions. The binding complementarity facilitates a selective and efficient assembly of [c2]daisy chain structures, inhibiting the creation of by‐products. Introducing multiple recognition sites confers the system with contraction and stretching motion actuated by chemical stimuli. The rate of this muscle‐like motion is calculated to be 0.8 s−1, which is 107 times faster than that of complex dissociation.

Funder

National Natural Science Foundation of China

Hubei Provincial Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology

Publisher

Wiley

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