Imino‐ and Azasugar Protonation Inside Human Acid β‐Glucosidase, the Enzyme that is Defective in Gaucher Disease-Reference-Cited by-同舟云学术

Imino‐ and Azasugar Protonation Inside Human Acid β‐Glucosidase, the Enzyme that is Defective in Gaucher Disease

Published:2020-04-22 Issue:26 Volume:59 Page:10466-10469
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Matassini Camilla¹,Warren Julia²,Wang Bo²,Goti Andrea¹,Cardona Francesca¹,Morrone Amelia³,Bols Mikael²^ORCID

Affiliation:

1. Department of Chemistry “Ugo Schiff” University of Florence Via della Lastruccia 13 50019 Sesto Fiorentino (FI) Italy

2. Department of Chemistry University of Copenhagen Universitetsparken 5 2100 Copenhagen Denmark

3. Paediatric Neurology Unit and Laboratories, Neuroscience Department Meyer Children's Hospital, and Department of Neurosciences Pharmacology and Child Health University of Florence Viale Pieraccini 24 50139 Firenze Italy

Funder

Statens Naturvidenskabelige Forskningsrad

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202002850

Reference21 articles.

1. Structure of acid β-glucosidase with pharmacological chaperone provides insight into Gaucher disease

2. X‐ray structure of human acid‐β‐glucosidase, the defective enzyme in Gaucher disease

3. Crystal Structures of Complexes of N-Butyl- and N-Nonyl-Deoxynojirimycin Bound to Acid β-Glucosidase

4. N-Hexyl-0-glucosyl sphingosine, an inhibitor of glucosyl ceramide, β-glucosidase

5. Human Acid ß-Glucosidase: Inhibition Studies Using Glucose Analogues and pH Variation to Characterize the Normal and Gaucher Disease Glycon Binding Sites

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