Sucrose‐Powered Liposome Nanosensors for Urinary Glucometer‐Based Monitoring of Cancer

Author:

Zhou Dongtao1,Zhang Zhibin1,Pan Liqing1,Wang Yanyi1,Yang Jingjing2,Gao Yanfeng3,Song Yujun1ORCID

Affiliation:

1. State Key Laboratory of Analytical Chemistry for Life Science College of Engineering and Applied Sciences Nanjing University Nanjing 210023 China

2. Department of Biochemistry and Molecular Biology Department School of Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Nanjing University of Chinese Medicine Nanjing 210023 China

3. School of Medical Imaging Wannan Medical College Wuhu 241002 China

Abstract

AbstractTimely detection of early‐stage cancer holds immense potential in enhancing prognostic outcomes. There is an increasing desire for versatile tools to enable simple, sensitive, and cost‐effective cancer detection. By exploiting the extraintestinal metabolic inertness and efficiency renal clearance of sucrose, we designed a liposome nanosensor using sucrose as a messenger to convert tumor‐specific esterase activity into glucose meter readout, enabling economical and sensitive urinalysis for cancer detection in point‐of‐care testing (POCT). Our results demonstrate that the nanosensors exhibited significant signal differences between tumor‐bearing and healthy mice in both orthotopic and metastatic tumor models. Additionally, efficient elimination of the nanosensors through the hepatobiliary pathway was observed with no significant toxicity. Such a non‐invasive diagnostic modality significantly assists in personalized pharmacological treatment and follow‐up efficacy assessment. We envision that this modular liposome nanosensor platform might be applied for economically detecting diverse diseases via a simple urinary test.

Funder

National Natural Science Foundation of China

State Key Laboratory of Analytical Chemistry for Life Science

Publisher

Wiley

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