Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein-Reference-Cited by-同舟云学术

Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein

Published:2021-03-24 Issue:18 Volume:60 Page:10172-10178
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Smola Miroslav¹^ORCID,Gutten Ondrej¹^ORCID,Dejmek Milan¹^ORCID,Kožíšek Milan¹^ORCID,Evangelidis Thomas¹^ORCID,Tehrani Zahra Aliakbar¹^ORCID,Novotná Barbora¹^ORCID,Nencka Radim¹^ORCID,Birkuš Gabriel¹^ORCID,Rulíšek Lubomír¹^ORCID,Boura Evzen¹^ORCID

Affiliation:

1. Gilead Sciences Research Centre at IOCB Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences Flemingovo náměstí 2 16610 Prague Czech Republic

Funder

Grantová Agentura České Republiky

Ministerstvo Školství, Mládeže a Tělovýchovy

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202016805

Reference47 articles.

1. How Does a Drug Molecule Find Its Target Binding Site?

2. Ligand-Binding Affinity Estimates Supported by Quantum-Mechanical Methods