Point‐of‐Care Testing for the Detection of MicroRNAs: Towards Liquid Biopsy on a Chip

Author:

Moro Giulia1,Fratte Chiara Dalle2,Normanno Nicola3,Polo Federico45,Cinti Stefano1ORCID

Affiliation:

1. Department of Pharmacy University of Naples Federico II Via Montesano 9 80131 Naples Italy

2. Department of Medical Biotechnology and Translational Medicine Postgraduate School of Clinical Pharmacology and Toxicology University of Milan “Statale” Via Vanvitelli 32 20133 Milan Italy

3. Cell Biology and Biotherapy Unit Istituto Nazionale Tumori (IRCCS), Fondazione Pascale Via Mariano Semmola, 53 80131 Naples Italy

4. Department of Molecular Sciences and Nanosystems Ca' Foscari University of Venice Via Torino 155 30172 Venice Italy

5. European Centre for Living Technology (ECLT) Ca' Foscari University of Venice Ca' Bottacin 30124 Venice Italy

Abstract

AbstractPoint‐of‐care (PoC) testing is revolutionizing the healthcare sector improving patient care in daily hospital practice and allowing reaching even remote geographical areas. In the frame of cancer management, the design and validation of PoC enabling the non‐invasive, rapid detection of cancer markers is urgently required to implement liquid biopsy in clinical practice. Therefore, focusing on stable blood‐based markers with high‐specificity, such as microRNAs, is of crucial importance. In this work, we highlight the potential impact of circulating microRNAs detection on cancer management and the crucial role of PoC testing devices, especially for low‐income countries. A detailed discussion about the challenges that should be faced to promote the technological transfer and clinical use of these tools has been added, to provide the readers with a complete overview of potentialities and current limitations.

Funder

Fondazione AIRC per la ricerca sul cancro ETS

Publisher

Wiley

Subject

General Chemistry,Catalysis

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3