Affiliation:
1. Dipartimento di Scienze Chimiche della Vita e della Sostenibilità Ambientale Università di Parma Parco Area delle Scienze17/A 43124 Parma Italy
2. Institut für Organische und Biomolekulare Chemie Georg-August-Universität Göttingen Tammannstraße 2 37077 Göttingen Germany
Abstract
AbstractWe report an unprecedented iron‐catalyzed C−H annulation using readily available 2‐vinylbenzofurans as the reaction pattern. The redox‐neutral strategy, based on cheap, non‐toxic, and earth‐abundant iron catalysts, exploits triazole assistance to promote a cascade C−H alkylation, benzofuran ring‐opening and insertion into a Fe−N bond, to form highly functionalized isoquinolones. Detailed mechanistic studies supported by DFT calculations fully disclosed the manifold of the iron catalysis.