Affiliation:
1. State Key Laboratory and Institute of Elemento-Organic Chemistry Haihe Laboratory of Sustainable Chemical Transformations Frontiers Science Center for New Organic Matter College of Chemistry Nankai University 94 Weijin Road Tianjin 300071 China
Abstract
AbstractHerein, we report a one‐pot method for enantioselective C−H allylation of pyridines at C3 via tandem borane and palladium catalysis. This method involves borane‐catalyzed pyridine hydroboration to generate dihydropyridines, then palladium‐catalyzed enantioselective allylation of the dihydropyridines with allylic esters, and finally air oxidation of the allylated dihydropyridines to afford the products. This method enables the introduction of an allylic group at C3 with excellent regio‐ and enantioselectivities.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Natural Science Foundation of Tianjin City
Subject
General Chemistry,Catalysis
Cited by
18 articles.
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