Structurally Simple Osmium(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy in the Near Infrared**

Author:

Mani Asma12,Feng Tao34ORCID,Gandioso Albert1ORCID,Vinck Robin1ORCID,Notaro Anna1ORCID,Gourdon Lisa1ORCID,Burckel Pierre5,Saubaméa Bruno6ORCID,Blacque Olivier7ORCID,Cariou Kevin1ORCID,Belgaied Jamel‐Eddine2ORCID,Chao Hui34ORCID,Gasser Gilles1ORCID

Affiliation:

1. Chimie ParisTech PSL University, CNRS Institute of Chemistry for Life and Health Sciences Laboratory for Inorganic Chemical Biology 75005 Paris France

2. National Institute of Applied Sciences and Technology Carthage University EcoChimie Laboratory Tunis Tunisia

3. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-Sen University Guangzhou 510006 P. R. China

4. MOE Key Laboratory of Theoretical Organic Chemistry and Functional Molecule School of Chemistry and Chemical Engineering Hunan University of Science and Technology Xiangtan 400201 P. R. China

5. Université de Paris Institut de physique du globe de Paris, CNRS 75005 Paris France

6. Cellular and Molecular Imaging Platform, US 25 Inserm, UMS 3612 CNRS Faculté de Pharmacie de Paris Université Paris Cité 75006 Paris France

7. Department of Chemistry University of Zurich Winterthurerstrasse 190 8057 Zurich Switzerland

Abstract

AbstractFive osmium(II) polypyridyl complexes of the general formula [Os(4,7‐diphenyl‐1,10‐phenanthroline)2L]2+ were synthesized as photosensitizers for photodynamic therapy by varying the nature of the ligand L. Thanks to the pronounced π‐extended structure of the ligands and the heavy atom effect provided by the osmium center, these complexes exhibit a high absorption in the near‐infrared (NIR) region (up to 740 nm), unlike related ruthenium complexes. This led to a promising phototoxicity in vitro against cancer cells cultured as 2D cell layers but also in multicellular tumor spheroids upon irradiation at 740 nm. The complex [Os(4,7‐diphenyl‐1,10‐phenanthroline)2(2,2′‐bipyridine)]2+ was found to be the most efficient against various cancer cell lines, with high phototoxicity indexes. Experiments on CT26 tumor‐bearing BALB/c mice also indicate that the OsII complexes could significantly reduce tumor growth following 740 nm laser irradiation. The high phototoxicity in the biological window of this structurally simple complex makes it a promising photosensitizer for cancer treatment.

Funder

H2020 European Research Council

Publisher

Wiley

Subject

General Chemistry,Catalysis

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